Four major nonprofit health systems—Baylor Scott & White, Memorial Hermann, Novant Health, and Providence—have launched Longitude Health, a for-profit holding company aimed at enhancing care delivery and performance through collaboration. The initiative focuses on developing impactful capabilities, such as improved patient billing transparency and care coordination, while ensuring that any profits support the nonprofit missions of its members. Longitude plans to establish multiple operating companies, with the first targeting the distribution of costly monoclonal antibodies and enhancing care for Medicare beneficiaries.